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Incretin Pathways Influencing Reward Circuits Incretin-based medications such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonists, including tirzepatide, have become important treatments for obesity and diabetes
additionally, several randomized studies have demonstrated improvements in hepatic steatosis and metabolic markers in populations with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis [28,29,30]
Genetic factors, baseline body weight, lifestyle habits, and adherence influence outcomes
Our previous work concluded that this was a consequence of glucagon deficiency rather than improved insulin sensitivity or secretion, as determined by a hyperinsulinaemiceuglycaemic clamp and an IVGTT [9]
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